Rash on the body after playing the hand, foot and mouth vaccine may be caused by drug reaction, allergy and other reasons, can be dealt with through good skin cleaning, oral medication and so on. 1. Drug reaction: after the hand-foot-mouth vaccine, the local skin is stimulated by a certain component of the vaccine, there is a drug reaction, which can lead to some patients with a rash. This is usually a normal adverse reaction to the HFMD vaccine, and it is necessary to do a good job of cleaning the local skin and not to scratch with the hands. Usually after rest and adjustment, this symptom will be gradually relieved. 2. Allergy: The patient’s body is special, after the HFMD vaccine may be allergic to the situation, which can lead to allergic symptoms such as rashes on the body. In this case, under the guidance of the doctor, oral loratadine tablets, chlorpheniramine maleate tablets and other antihistamines, to play the role of anti-allergy, medication to follow the doctor’s instructions, not self-medication. After playing the hand, foot and mouth vaccine rash appeared on the body, must actively consult a professional doctor to deal with, to avoid the adverse consequences of improper treatment.