Smaller gallbladder size may be due to individual differences or physiological manifestations related to eating, as well as pathological conditions such as cholecystitis, with reference to ultrasound and other auxiliary examinations and related manifestations. If the size of the gallbladder becomes smaller under ultrasound and other examinations, and if it is not accompanied by clinical manifestations such as right upper abdominal pain and dyspepsia, the first thing to consider is that it may be due to individual differences or factors such as the angle of the examination, or the decrease in the size of the gallbladder after the discharge of bile from the gallbladder after eating, which is a normal physiological condition, and there is no need to be overly concerned about it. In addition, the decrease in gallbladder size should also be on the alert for gallbladder stones, cholecystitis, and peripheral adhesions, atrophy and fibrosis of the gallbladder, which may be accompanied by fever, abdominal pain and dyspepsia and other clinical signs. It is recommended that the gallbladder should be shrunken with obvious signs and symptoms, and should be treated with surgery or medication after ultrasound and other auxiliary examinations are performed to determine the cause of the disease.