The normal endometrium is affected by the menstrual cycle and undergoes periodic exfoliation. There are two types of endometrial shedding. The first is physiological endometrial exfoliation, which is caused by cyclical fluctuations in female ovarian hormone levels and does not require treatment. Secondly, irregular endometrial exfoliation caused by endocrine disorders in women may lead to irregular vaginal bleeding. In this case, estrogen, progestin, or estrogen-progestin combination can be added according to the patient’s hormone level and disorder. If it is caused by luteal insufficiency, progestin can be added after ovulation, such as digestrol tablets or progesterone soft capsules, for 14 days, and regular menstruation will usually occur after stopping the medication. If it is due to a woman’s low estrogen level, you can add supplemental Glaxo on days 1-5 of menstruation for a total of 21 days, and add dydrogesterone tablets or progesterone soft capsules for the last 10 days for cyclical treatment.