Headache with brow bone pain may be caused by frontal sinusitis. The patient usually has a heavy headache in the morning and a lighter headache in the afternoon, and may also have nasal congestion and runny nose, mainly anti-inflammatory treatment, the commonly used drugs clinically are tinidazole, metronidazole and cephalosporin antibiotics, if the patient is in the chronic stage, there may also be memory loss and inattention, and at the same time can apply drugs to improve brain metabolism for treatment, the commonly used drugs are olacetam and piracetam. If necessary, puncture irrigation can also be performed. It may also be caused by trigeminal neuralgia, which is usually episodic, lasting from a few seconds to a few minutes, and can stop suddenly, with several or even dozens of attacks per day. If medication is not effective and the pain is severe, radiofrequency ablation can be considered.