The whole body wasting type refers to the human body weight loss due to disease or certain factors, below 10% of the standard weight is wasting (some authors believe that where the weight is more than 10% lower than the standard weight is thin, below 20% or more is called wasting) the whole body wasting type of differential diagnosis: 1, physical wasting for non-progressive, often with a family history, no etiology can be found. 2, organic disease wasting (1) hypothalamic syndrome (2) hypopituitarism wasting (3) primary chronic hyperalgesia (4) hyperthyroidism (5) diabetes mellitus 3, neurological (psychogenic) anorexia Most often seen in young women, with psychogenic factors as a trigger, manifested by emotional disorders, fear of being too fat and refusing to eat, denying hunger, denying wasting. Long-term refusal to eat leads to inadequate nutrition of calories and protein, rapid weight loss and even cachexia, amenorrhea, bradycardia, lower body temperature, but no hair loss, and may have an increase in coital hair. The development of secondary sexual characteristics is normal. Plasma FSH, LH and estrogen levels may be reduced, thyroid function tests and adrenal cortical function are normal. The gonadal function may return to normal after the nutritional status is restored. 4, other diseases that cause wasting Chronic wasting diseases: malignant tumors, chronic infectious diseases, chronic infectious diseases such as AIDS and schistosomiasis, etc. Diagnosis. Digestion and absorption disorders caused by wasting: mainly seen in oral and pharyngeal, esophageal cardia, gastrointestinal diseases, pancreatic and hepatobiliary diseases. 5, malnutrition wasting Most often seen in infants and young children, when famine and war occur. Lack of food plaque, lack of energy (or) protein. The main manifestations are weight loss, emaciation, loss of subcutaneous fat, growth retardation, edema. Decreased function of organs of various systems, etc. It is also accompanied by manifestations of vitamin deficiency, anemia, and low immunity prone to secondary infections. Laboratory tests often show anemia, decreased plasma proteins (especially clear proteins), decreased blood lipids, and often lower than normal potassium and magnesium. Thyroid function may be low. The adrenal cortex is normally responsive to ACTH.