There are many reasons for itchy skin after kidney transplantation, which may be normal, or can be seen in drug allergy, or may be the manifestation of some kind of postoperative complications, such as renal insufficiency, renal transplantation rejection and so on. 1. Normal situation: Itchy feeling may appear after the skin incision is healed after kidney transplantation, and it can be relieved by itself, which is normal and no special treatment is needed. 2. Drug allergy: after kidney transplantation, you may take some medicines, if the medicines are not taken properly, it may cause drug allergic reaction and lead to skin itching. 3. Renal insufficiency: it is a clinical syndrome caused by the decline of renal function, which can be caused by renal transplantation surgery, acute kidney injury and other factors. The main symptoms can be seen as reduced appetite, fatigue, itchy skin and so on. 4. Kidney transplantation rejection reaction: it is a disease caused by immunopathological reaction between transplanted kidney and recipient, which can be caused by cellular reaction, antibody-mediated vascular reaction and other factors. The main symptoms can be seen as fever, hematuria, elevated blood pressure, etc., occasionally accompanied by skin itching. If itchy skin occurs after kidney transplantation, you should go to the hospital immediately and undergo the relevant examinations in order to clarify the cause of the disease and actively cooperate with the doctor’s treatment.