The treatment of thyroid nodule 2cm with calcification needs to be differentiated into different situations: benign thyroid nodule without symptoms can be observed regularly; malignant thyroid nodule needs to be treated by surgery. Thyroid nodule 2 cm with calcification is a diagnostic result of thyroid ultrasonography, and its treatment needs to be formulated in different situations. If the nodule is asymptomatic benign thyroid nodule with calcification and the thyroid function is normal, regular checkups are enough and no special treatment is needed; if it is a benign thyroid nodule with hyperthyroidism, anti-thyroid medication such as methimazole should be taken; if it is a benign thyroid nodule with hypothyroidism, patients should be treated with levothyroxine sodium tablets. If the ultrasound shows small calcifications in the form of corn grains, the possibility of malignant thyroid nodules is high, and a thyroid puncture biopsy is needed to determine the nature of the thyroid nodules, and surgical resection should be considered once the diagnosis of malignant thyroid nodules has been confirmed. If you have a thyroid nodule measuring 2 cm with calcification, it is recommended that you go to the hospital and ask your doctor to make a judgment.