Wandering joint pain is a clinical manifestation, mainly seen in rheumatoid arthritis, gout and so on. 1. Rheumatoid arthritis: mainly manifested as wandering and multiple large arthritis; local redness, swelling, burning, pain and tenderness can occur; often no obvious joint degeneration after relief, but easy to repeat; aggravation of joint symptoms is related to cold and humidity. 2. Gout: acute arthritis of gout can appear in the affected joints red, swelling, heat, pain and dysfunction, unilateral 1st metatarsophalangeal joints are the most common; the chronic phase is mostly seen in patients without standardized treatment, the affected joints are asymmetric irregular swelling, pain, and can involve multiple joints, such as dorsum of the foot, ankle, heel, knee, wrist, fingers, toes and elbow joints. Wandering joint pain should be timely to the hospital to identify the cause of the disease and targeted treatment.