Whether a 3.5 x 6.0 cm ulcer visible in the upper middle esophagus is serious depends on the extent of the disease and whether lesions occur on the ulcer surface to determine, if the pathology is malignant is more serious. If the pathology is malignant, it is more serious. If there is no abnormality in the pathology of the ulcer in the middle esophagus and the ulcer is a simple esophageal ulcer without malignant or malignant tendency, then it is not serious. If there is malignancy or malignant tendency on further endoscopic biopsy and pathologic screening of mid-esophageal ulcer, it may turn into esophageal cancer in later stage, and this situation is more serious. Therefore, if there is an ulcer of 3.5×6.0cm in the upper and middle esophagus, it is necessary to do further endoscopic examination of the esophagus, and take tissues from the ulcer surface for pathological tests. Determine the extent of the disease, so that according to the extent of the disease to take timely treatment measures. Esophageal ulcers, pay attention to the usual diet light, eat more well-digested food to avoid eating cold stimulating food so as not to aggravate the condition. If there is any discomfort, consult a doctor in time.