Dobutamine refers only to compound levodopa, a combination of benserazide plus levodopa, and this drug is to be used in combination with dopa receptor agonists or monoamine oxidase inhibitors. Dope-receptor agonists mainly include non-ergot dope-receptor agonists, ergot dope-receptor agonists, the latter is no longer advocated, the former mainly includes piribedil, ropinirole, pramipexole, pramipexole is currently recommended as the drug of choice. Monoamine oxidase inhibitors are mainly able to stop the degradation of dopamine in the brain and play a role in increasing the concentration of dopamine in the brain, and the ones that are currently used more often are selagiline, and resagiline. It is important to start with small doses of each drug and adjust the dose gradually to prevent patients from not tolerating the side effects.