Urinary blockage and painful urination with no effect of levofloxacin is considered to be caused by urinary blockage and painful urination due to urethral stone, prostate hyperplasia and other diseases, rather than due to urinary system infection. Playing levofloxacin generally refers to levofloxacin injection, which is a quinolone antibacterial drug, can be used to treat respiratory infections caused by sensitive bacteria, urinary system infections, reproductive system infections and other diseases. If the urinary tract blockage and painful urination caused by urinary system infection can be treated with this product. If the treatment is ineffective, it is considered to be caused by urinary stones, prostate hyperplasia and other diseases, with different etiology, the treatment is different, and medication, surgery and other means can be taken. 1. Urethral stones: can cause urinary blockage, and may be accompanied by urinary difficulties, hematuria, urinary pain and other symptoms, and the pain will radiate to the head of the penis. Patients can choose surgical treatments such as urethrotomy and transperineal urethrotomy after evaluation by the doctor. 2. Prostatic hyperplasia: Prostatic epithelial and mesenchymal hyperplasia can press the urethral orifice, leading to urinary blockage, and may be accompanied by frequent urination, urinary pain, urinary retention and other phenomena. Patients can use drugs such as terazosin and tamsulosin as prescribed by the doctor, or undergo surgical treatment such as prostatectomy. In addition, urological tumors and other diseases can also cause this phenomenon, it is recommended that patients go to the hospital in a timely manner, after clarifying the cause of the disease, as soon as possible to receive treatment, to avoid blind use of drugs.