The main manifestations of the deterioration of tuberculosis are as follows: 1. The toxic symptoms of tuberculosis become more and more serious, such as persistent low or even high fever, accompanied by coughing, coughing up a large amount of purulent sputum, hemoptysis, and there will be symptoms of respiratory distress such as wheezing, shortness of breath, chest tightness, chest pain, etc., and they are accompanied by loss of appetite, lethargy, fatigue, and depression, etc.2. A large amount of pleural effusion presses on the lungs thus causing the Further aggravation of dyspnea.3. Inflammation of extrapulmonary tuberculosis foci, such as tuberculous meningitis leading to nausea, vomiting, severe headache, drowsiness and coma.