Indirectly elevated bilirubin is mostly due to liver and gallbladder diseases, hemolytic diseases or physiological factors, which can be alleviated by adjusting lifestyle and diet, medication and surgical treatment. 1. Adjustment of lifestyle and diet: patients should pay attention to maintain sufficient sleep, avoid staying up late, overwork, etc., quit smoking and drinking, maintain a light diet, avoid eating cholesterol-rich foods such as animal offal. Indirect bilirubin elevation caused by physiological factors such as staying up late and alcohol abuse usually requires no special treatment. 2. Drug treatment: the use of drugs should be targeted according to different causes. (1) If the elevation is caused by fatty liver, alcoholic liver, hepatitis, cirrhosis, etc., drugs such as reduced glutathione, S-adenosylmethionine, silymarin, etc. can be taken to protect liver cells. (2) If it is caused by gallbladder stones, bile duct stones and other diseases, ursodeoxycholic acid and other choleretic drugs can be taken. (3) If it is caused by hemolytic anemia or other diseases, glucocorticoid drugs, cyclophosphamide, folic acid or iron can be taken. 3. Surgery: Surgery can be considered for patients who have gallbladder stones, bile duct stones and other diseases. For patients with long-term or recurrent elevated indirect bilirubin, it is recommended to consult a doctor in a timely manner to identify the cause of the disease under the guidance of a professional physician and carry out targeted treatment. The medication should be taken in strict accordance with the doctor’s instructions, and should not be used on its own, so as not to delay or even aggravate the condition.