Metformin enteric-coated tablets and extended-release tablets are manufactured with different processes, and there are differences in the speed of action and maintenance time, so patients are advised not to replace them on their own. Metformin enteric-coated tablets start to release the drug effect only after reaching the intestine, the drug effect is maintained for a short time, and cleared rapidly, the plasma half-life is 1.7-4.5 hours, and 90% of the drug is cleared within 12 hours. Metformin extended-release tablets are manufactured through a special process, after entering the patient’s body, stable and slow release, the time to reach the steady-state blood concentration is 24-48 hours, the efficacy of the drug is maintained for a long time. There is a difference between metformin hydrochloride enteric-coated tablets and metformin hydrochloride extended-release tablets, and it is recommended that patients follow the doctor’s instructions to use the drug, and should not be changed on their own, so as to avoid any impact on the treatment process.