The management of high alkaline phosphatase depends on the specific cause. If the cause is due to life and diet, usually no medication is needed; if the cause is due to disease, the medication needed is vitamin D, entecavir, etc. Sometimes surgery, radiotherapy and other treatment measures are also needed. 1. Diet and treatment: high alkaline phosphatase can be caused by growth and development, late pregnancy, etc. Usually the value will not be higher than 3 times of the normal value, which does not need special treatment, and it can be relieved by removing the triggers. 2. Disease causes and treatment: choose treatment measures according to specific diseases. Obstructive jaundice needs to be treated according to the cause, such as cholelithiasis, etc., and surgery is needed if necessary; rickets needs to be supplemented with vitamin D and calcium tablets; viral hepatitis needs to be given entegravir, tenofovir and other medicines according to the doctor’s prescription; bone malignant tumor, liver cancer, etc., need to consider surgery, radiotherapy and other measures. It can also be seen in hyperparathyroidism, infectious mononucleosis and other causes, which can be treated with medication. For the treatment of high alkaline phosphatase, it is recommended that patients go to the hospital in time, to clarify the cause and then make specific plans. Drugs need to be used under the guidance of a doctor.