The conversion of hepatitis B carriers can be seen in the following three situations: 1. Spontaneous immune clearance, the immune status of hepatitis B carriers is active when they enter young adulthood, there will be spontaneous immune clearance, i.e., E antigen, E antibody conversion and S antigen, S antibody conversion, which manifests itself in the form of an acute attack of slow hepatitis B. 2. Interferon, there is a certain rate of negative conversion, currently the rate of E antigen negative conversion is around 35% and the rate of surface antigen negative conversion is The rate of negative E antigen is currently around 35% and the rate of negative surface antigen is around 10%. However, interferon has some adverse reactions in clinical application, patients will have some concerns about its application. 3, oral antiviral drugs, such as tenofovir and telbivudine, whose main mechanism of action is to inhibit the replication of the virus, there are reports of the application of the relevant antigens and antibodies to turn negative.