High serum gastrin is associated with Helicobacter pylori infection and gastrinoma, which can induce gastritis, gastric ulcer, atrophic gastritis and other diseases. H. pylori is a pathogen that is able to parasitize in the acidic environment of the stomach. H. pylori can cause some damage to the mucosa of the stomach wall, but also affect the secretion of digestive juices, and many patients will have increased serum gastrin as a result. Increased serum gastrin will affect the gastric acid environment, resulting in the digestive system for a long time in the state of gastric acid, these people are more likely to suffer from gastritis, gastric ulcer and other diseases. Long-term elevated gastrin also affects the gastric glands, leading to atrophy of the glands and inducing atrophic gastritis. The high serum gastrin seen in some people is directly related to gastrinomas. Gastrinomas are often located between the pancreas and the duodenum, and the onset of the condition is associated with an overproduction of gastric acid. The disease affects the function of gastrin secretion, leading to hypersecretion of gastrin.