Durian and milk taken together are usually not toxic, but it is not recommended to take durian and milk together. Because durian is rich in vitamins and trace elements, it also contains histamine, an inflammatory mediator that increases capillary permeability and aggravates allergic reactions in the body, This can lead to nausea, acid reflux, heartburn, abdominal pain, and even diarrhea, especially in the form of watery stools. In addition, durian is rich in vitamins, especially after drinking milk, which can cause non-absorption and intolerance of some vitamins, and also affect the digestion and absorption of proteins in milk in the gastrointestinal tract. Therefore, it is recommended to try to drink milk after eating durian at least one hour apart.