There are many diseases that cause chest tightness and shortness of breath, mainly including the following: i. cough variant asthma of the respiratory tract, severe pneumonia, chronic obstructive pulmonary disease, severe tuberculosis or tumors, with symptoms of chest tightness and shortness of breath; ii. cardiac insufficiency; iii. psychiatric factors. The treatment of different cases is different, patients with chest tightness and shortness of breath due to cough-variant asthma of the respiratory tract need to inhalation of Cymbalta, Sulidia, oral Menlust sodium, avoid contact with allergens and so on. If the patient has chest tightness and shortness of breath due to chronic obstructive pulmonary disease, inhalation of bronchodilators, oral theophyllines, etc. are needed. If the patient develops chest tightness and shortness of breath due to cardiac insufficiency, anti-heart failure therapy is needed.