Hypoxemia with hypercapnia in respiratory failure requires oxygen inhalation to correct the hypoxic state, as well as active treatment for the primary disease, and treatment with ventilator therapy if necessary. 1. Oxygen intake, usually requires low-flow oxygen, because inhalation of high-flow oxygen may inhibit respiration and aggravate hypercapnia. 2. Etiological treatment, such as acute exacerbation of chronic obstructive pulmonary disease resulting in hypoxemia and hypercapnia, may require intravenous use of methylprednisolone and other glucocorticoid drugs; if there is a bacterial infection, may also need to use moxifloxacin and other antibiotics; wheezing need to be given to asthma treatment, such as nebulized inhalation of terbutaline, ipratropium bromide, and other drugs. 3. The use of ventilator, some patients may need non-invasive mechanical ventilation, such as acute respiratory failure, may even need tracheal intubation, invasive mechanical ventilation. Respiratory failure hypoxemia with hypercapnia needs to be treated for the primary disease, and at the same time actively deal with the hypoxia situation, specific need to receive individualized treatment under the guidance of the doctor.