High alpha-fetoprotein for 4 consecutive years may be related to hepatitis, cirrhosis, hepatocellular carcinoma, etc., which can be treated with medication, surgery, etc. as prescribed by the doctor. 1. Hepatitis, cirrhosis: patients need to undergo further examination of liver function, hepatitis B, hepatitis C as well as ultrasound, magnetic resonance, etc., in order to clarify the cause. If it is viral hepatitis, antiviral treatment and liver-protecting treatment should be carried out. If it is cirrhosis, symptomatic treatment should be actively carried out on the basis of etiologic treatment. 2. Hepatocellular carcinoma: If alpha-fetoprotein is persistently elevated and malignant disease is suspected, liver magnetic resonance should be examined to clarify whether there is a lesion and puncture biopsy should be performed to find out whether it is primary hepatocellular carcinoma, and interventional therapy and surgery can be performed if necessary. In addition, gastric cancer, pancreatic cancer, embryonic tumors of the gonads and so on can also lead to elevated alpha-fetoprotein. It is recommended to go to the hospital in time for medical consultation to clarify the cause of the disease, and then carry out targeted treatment under the guidance of the doctor to minimize the adverse effects of the disease.