Anti CCP antibody value is higher than the upper limit of the normal reference range is mainly seen in rheumatoid arthritis, need to further improve the relevant examination, after a clear diagnosis to be targeted drug therapy or other treatments, after treatment the antibody level may decline. Anti-CCP antibody, i.e. anti-cyclic citrullinated peptide antibody, is a kind of autoantibody mainly of lgG type, which is closely related to rheumatoid arthritis, and the positive rate of this antibody in early stage patients is about 80%. Positive antibody can also be seen in connective tissue diseases, tumors and other diseases, which need to be further perfected relevant examinations, and be treated with targeted medication or other treatments after a clear diagnosis. Anti-CCP antibody has high sensitivity and specificity for rheumatoid arthritis, which is treated with non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, anti-rheumatic drugs (ARDs) such as methotrexate, glucocorticosteroids (glucocorticosteroids) such as prednisone, and biologics (biologics) such as infliximab, and the treatment plan should be tailored to the specific condition of the patient. Antibody levels may decrease after standardized treatment. Laboratory test results need to be interpreted by a professional physician. It is recommended that patients with high anti-CCP antibodies go to the Department of Rheumatology and Immunology of a regular hospital for further relevant examinations to make a clear diagnosis.