Prilosec antihypertensive drugs and sartans have good blood pressure lowering effect, it is impossible to judge which drug type is better, mainly for different patients and physical quality, choose the best antihypertensive drugs for their own treatment. Both drugs have the same antihypertensive mechanism, can inhibit vasoconstriction to achieve the effect of lowering blood pressure, but also can diastole venous blood vessels. The contraindications of these two are also almost the same, such as pregnancy hypertension, unilateral renal artery stenosis, bilateral renal artery stenosis of the crowd prohibited the use of such drugs. Patients who need to take oral antihypertensive drugs are advised to go to the hospital in time, complete the relevant examinations, and follow the doctor’s instructions to choose the appropriate antihypertensive drugs.