Large blood pressure difference may be due to the decline in elasticity of the aorta, aortic valve closure insufficiency and other factors, can be adjusted through drugs and food, if necessary, need surgical treatment, the therapeutic effect varies from person to person, there is no such thing as the fastest, the most effective method. 1. Decrease in elasticity of large arteries: When the elasticity of large arteries decreases, the common cause is atherosclerosis, which will make the elasticity of large blood vessels to reduce the ability to store blood, so that the difference in blood pressure increases. Attention should be paid to improve lifestyle, light diet, do not eat high salt, high blood fat food, more exercise, pay attention to rest, avoid mental stress. Oral lipid-lowering drugs such as simvastatin and atorvastatin should be taken as prescribed by the doctor. 2. Aortic valve insufficiency: due to rheumatism, congenital malformation and other factors, aortic valve insufficiency, diastolic blood regurgitation, diastolic blood pressure decreases, blood pressure difference increases, through the above mentioned to improve the lifestyle to regulate, drugs such as hydralazine, nifedipine, etc. has a certain degree of therapeutic effect, if accompanied by the situation of the left heart insufficiency, should be carried out as soon as possible for valvular surgical treatment. When there is a big difference in blood pressure, it is recommended to go to the hospital to improve the cardiac ultrasound, thoracic aortic ultrasound examination, to clarify the cause of the disease, and to carry out treatment as soon as possible.