In recent years, with the increasing incidence of gonorrhea, the incidence of neonatal gonorrheal conjunctivitis has increased accordingly, and the trend is increasing year by year. Gonococcal conjunctivitis is one of the most damaging acute eye diseases in newborns, and improper treatment can cause serious damage to eye tissues, so early prevention, proper diagnosis and timely treatment are needed to minimize its harmful effects. The clinical symptoms vary in severity, with varying degrees of eyelid edema, difficulty in opening, and yellow secretions covering the lid fissure. A smear of the conjunctival bursa revealed Gram-negative diplococci in the leukocytes. Some children also have gonorrhea vulvovaginitis. Topical treatment: rinse the conjunctival sac, pay attention to the isolation of the healthy eye when rinsing, the head should be tilted to the affected side to prevent contamination of the healthy eye during rinsing. Topical antibiotic eye drops should be applied to the eye frequently (once every 2 hours). Systemic treatment: Intramuscular injection of penicillin or ampicillin for 5-7 days.