Grade III unclosed foramen ovale is defined as a foramen ovale with a diameter of ≥4 mm, which is usually without clinical symptoms and does not require special treatment; this condition is not serious. However, the presence of unexplained migraine, heart failure, etc. indicates that it is serious. Foramen ovale is the most common congenital heart disease, mostly closes at the age of 1 year, if it does not close at the age of 3 years for foramen ovale is not closed, which is mainly detected by ultrasound of the heart, usually there is no clinical symptom, and does not need special treatment. However, if unexplained migraine, stroke, heart failure, etc. occur, the consequences are serious, and should be timely medical treatment, such as interventional occlusion, to avoid life-threatening. Ovarian foramen magnum grade III should avoid exertion and heavy physical labor in daily life and maintain a good state of mind.