The treatment of generalized muscle tightness and stiffness needs to clarify the cause of the disease, and the main treatment modalities include physical therapy and drug therapy. 1. Physiotherapy: If the whole body muscle tightness and stiffness occurs due to high mental tension, shock, etc., the first step is to remove the causative factors, and the second step is to choose massage, electrotherapy, ultrasound and other physiotherapy to relieve the symptoms. Ultrasound can penetrate deep into the muscle tissue to generate heat energy, which can help relieve pain and swelling. Electrotherapy is the use of electromagnetic machines to make muscle cells move regularly to relieve muscle hardening and twitching. 2. Medication: Tightness and stiffness of muscles throughout the body can also occur when there is pain, infection, or some neurological conditions such as high spinal cord injury, craniocerebral injury, or Parkinson’s disease. These conditions often require pharmacologic interventions such as antibiotics, sedatives, anti-epileptic drugs, levodopa, etc. All of these medications should be used under medical supervision and avoid self-administration.