A map-like bone defect is one of the symptoms of Hand-Schüller-Christian disease. Hand-Schüller-Christian disease, also known as subacute or chronic differentiated histiocytosis, used to be called Han-Schüler-Coeur disease, which is different from Letterer-Siwe disease and eosinophilic granuloma of bone. granuloma of bone) are different manifestations of histiocytosis (Langerhans cell histiocytosis) because they share common histopathologic features, except that the age of onset is different, the clinical manifestations are different, there are acute and subacute differences, and the prognosis is also different. We can make a diagnosis based on the clinical manifestations. The disease is most frequent in children over 3 years of age and occurs rarely in adults. Patients develop ulcers or yellow tumors on the skin of the face, eyelids, trunk, perineum and axillae, and ulcers on the oral mucosa. Fibrosis of the hilar and interstitial lung due to histiocytic and inflammatory cell infiltration may cause right heart failure. Urogynecrosis occurs due to pituitary or hypothalamic involvement. The skull, pterygoid saddle of the skull base, maxilla and mandible, pelvis, femur, ribs, and humerus can be involved, especially limited, irregularly sized, irregularly bordered, well-defined, non-sclerotic defect areas that resemble a map, hence the name map-like bone defects. The orbital soft tissues may be involved in the destruction of the outer orbital wall and orbital parietal bone to produce orbital protrusion, but the true cause of orbital protrusion is unknown. In typical cases, the triad of cranial map-like defect, proptosis, and uveitis is present, but it is rare for all three symptoms to occur together; in atypical cases, the three features do not occur together, or only one or two of them are present, and uveitis is a late complication of the lesion.