The symptoms of thalassemia are mainly anemia, but the clinical manifestations are different according to the degree, mainly including α-pearl protein production disorder anemia and β-pearl protein production disorder anemia. 1. α-CPD anemia can be divided into four types: (1) The stationary type has no clinical manifestations and no anemia; (2) Mild anemia with or without symptoms, which may be aggravated by infection; (3) The intermediate type occurs mostly in children, with no obvious manifestations at birth, and symptoms begin to appear around the age of one week, with mild-to-moderate anemia, mostly accompanied by jaundice as well as hepatosplenomegaly and other symptoms; (4) The severe type occurs mostly in fetuses, with abortion occurring at 30-40 weeks or premature delivery and death within half an hour of birth, and is mainly characterized by severe anemia, edema, jaundice, pleural fluid, and other clinical manifestations. 2. β-pearl protein production disorder anemia can be divided into four types: (1) Static type without clinical symptoms; (2) Mild type with insignificant symptoms, with or without anemia; (3) The intermediate type often develops in early childhood, with moderate anemia, accompanied by hepatosplenomegaly and skeletal changes; (4) Children with severe type may have severe anemia, and may have progressive enlargement of liver and spleen, and malformation of bone development. If symptoms of thalassemia are suspected, please go to the hospital in time to identify the cause of the disease and give targeted treatment under the guidance of the doctor.