Bone marrow inflammation is a broad concept, generally due to the immune response of pathogenic microorganisms or various physical factors leading to bone erosion and destruction, accompanied by the body’s repair response. There are many factors, which can be broadly divided into infectious and non-infectious factors. Infectious mainly refers to pathogenic microorganisms, which are simply small organisms invading the body invisible to the naked eye and causing inflammation, and these pathogenic microorganisms commonly include bacteria, bone tuberculosis, fungi, and syphilis. Non-infectious factors are commonly found in about three types, namely, deformational osteitis, iliac dense osteitis, and SAPHO syndrome, as follows: 1. Deformational osteitis, most often seen in men over 40 years of age, generally has a family tendency to develop, mainly manifests as bone pain, which is detected due to elevated alkaline phosphatase or x-ray. The onset of the disease is in the pelvis, thigh bone, i.e. femur. x-ray with coarse trabeculae and thickened bone cortex is the main manifestation, bone scan can find multiple points of bones with radioactive concentration; 2, iliac dense osteitis, the iliac bone is in the hip of a person, iliac dense osteitis is dominated by pain in the sacroiliac joint, the sacroiliac joint is on the side of the iliac bone, the lower 1/3-2/3 of the bone density is increased causing pain, mainly osteosclerosis, is a nonspecific inflammatory disease. The disease often involves the iliac bone and sacrum, mainly in young and middle-aged women, the cause of the disease is mostly strain, pregnancy, childbirth caused by the sacroiliac joint lesions, the disease can be reduced or completely disappear after 3-20 years, the prognosis is relatively good; 3, SAPHO syndrome, manifested as a collection of five common symptoms together, there are periostitis that is inflammation of the periosteum, acne that is facial acne, pustules that is more common in the palms of the hands and feet, pustules, pustules, pustules, pustules. The syndrome is characterized by a prolonged and self-limiting course, with intermittent recurrence and remission.