The pain in the cheeks at night is considered to be caused by mumps, dry syndrome, temporomandibular arthritis and other diseases. 1. Mumps: some patients with mumps may have swollen parotid glands and fever, accompanied by pain in the cheeks, due to viral infection that may stimulate the parotid glands on both sides of the cheeks. 2. Dry Syndrome: Some patients with dry syndrome may experience pain in the cheeks due to the stimulation of exocrine glands, which may affect the body tissues and may be accompanied by dry mouth and eyes, dental caries and other symptoms. 3. Temporomandibular arthritis: some patients with temporomandibular arthritis may experience pain in the cheeks and increased pain when opening and closing the mouth for chewing due to the inflammatory reaction caused by the lesions in the temporomandibular joint tissues. If there are obvious symptoms of parotid pain, it is recommended to consult a doctor in time for examination and treatment.