There are two main adverse reactions to taking statins, namely effects on the liver and muscles. Specific adverse effects vary depending on the individual. 1. Effects on the liver: statins can cause liver enzyme increase, liver enzyme increase generally occurs within 12 weeks of the drug, the patient’s self-awareness of symptoms, jaundice, cholestasis or progression to liver failure is very rare, most of them can be recovered after stopping the drug. It is currently recommended that liver function should be followed up 6 to 12 weeks after statins are administered, and then once a year, or at the appropriate time after dose adjustment or when there are appropriate clinical symptoms. Liver enzymes exceeding the upper limit of normal value more than 2 times should be discontinued statins. 2. Effects on muscle: statins may cause myalgia (manifested as muscle pain or weakness without elevated creatine kinase), myositis (with muscle symptoms and elevated creatine kinase), and rhabdomyolysis (with muscle symptoms, significant elevation of creatine kinase more than 10 times the upper limit of normal and elevated creatinine, often with brown urine and myoglobinuria). Before taking statins, you need to consult your medical professional in detail.