For example, the skull is a group of hard skeletal tissues, which is a major protective barrier for the brain and nerve center, and plays a very important role in the health of the whole body, so if a cranial defect occurs, it should not be taken seriously. In the clinic, many patients’ cranial defects are left behind because of serious cranial trauma, or because they have to do craniotomy because of some cranial diseases. Some patients are in critical condition, and it is difficult for them to regain consciousness after surgery, and they are always in a coma, which makes their families more worried. In general, patients with cranial defects of more than 3cm after craniotomy and who meet the indications for surgery should have cranial repair surgery in time. Does cranial repair help patients to wake up? From a certain point of view, cranial repair surgery has some positive significance in promoting the awakening of patients with postoperative coma. After cranial repair, a complete and closed cranial environment is reshaped, which is conducive to the stabilization of intracranial pressure and the normal operation of cerebrospinal fluid and cerebral blood circulation, and helps the recovery of cerebral nerve function. However, the patient’s coma situation is relatively complicated, and it is not possible to guarantee whether he can really wake up. However, one thing is certain, the cranial cavity of the patient with cranial defect is incomplete, the external atmospheric pressure acts directly on the intracranial tissue, the intracranial pressure and intracranial environment are unstable, the cerebrospinal fluid and cerebral blood circulation will be impaired, and the cerebral nerve function will be affected, if the cranial defect is not repaired for such a long time, it will definitely be detrimental to the patient’s wakefulness.