Diabetes has now become a global health concern, with the total number of people with diabetes worldwide exceeding 100 million. China has become the second largest diabetic country in the world, after India, and the United States ranks third. The last decade has been the fastest growing decade for the number of Chinese residents with diabetes. Diabetes is still one of the major problems in the world, and so far it can only be controlled by medication but not completely cured, thus the medication for diabetes is very important. The effect of different types of hypoglycemic drugs, given at different times, is obviously different. The treatment of diabetes drugs can be summarized into six categories: a. Sulfonylurea insulin secretagogues: currently commonly used are glibenclamide (euglycemia), gliclazide (DAMAC), glipizide (donbeck), glimepiride, glipizide (sugar fit), etc. By binding to sulfonylurea drug receptors on the pancreatic beta-cell membrane, ATP-sensitive is closed potassium channels, the intracellular potassium ion outflow is reduced, the cell membrane is depolarized, calcium channels are opened, intracellular calcium ions are increased, and insulin release is promoted. The effect starts from 0.5 to 1 hour after oral administration and is strongest from 2 to 6 hours. Therefore, it should be taken 30 minutes before meal, and the time of strongest effect is consistent with the time of blood glucose elevation after eating, so as to play an effective glucose-lowering effect, which should be taken half an hour before meal. Second, non-sulfonylurea insulin secretagogues: such as Reglanet (Novaluron), Naglenet (Tangli), also acts on the pancreatic beta cells to stimulate insulin secretion, but its mechanism of action is different from the sulfonylurea. These drugs have a fast and short hypoglycemic effect, simulating the first phase of insulin physiological secretion, mainly used to control postprandial hyperglycemia, because of the characteristics of the drug fast in and fast out, so take immediately before meals, no meal without taking drugs. Third, biguanide hypoglycemic drugs: such as metformin, can increase the uptake and utilization of glucose by peripheral tissues (such as muscle and fat), and through the inhibition of glycogen isogenesis and glycogenolysis, reduce the output of liver sugar to control postprandial blood sugar. Such drugs should be taken during meals or immediately after meals to reduce the stimulation of the drug on the gastrointestinal tract. IV. α-glucosidase inhibitors: commonly used drugs are acarbose (bactrim, carboplatin), which can reduce postprandial hyperglycemia by inhibiting α-glucosidase (such as maltose, amylase, sucrase) on the surface of small intestinal mucosal epithelial cells and affecting the absorption of carbohydrates, and its dosing method is also special, and such drugs can only be chewed at the same time with the first meal to play a better therapeutic role. V. Insulin sensitizers: such as vindia (rosiglitazone), which is an agonist of highly selective peroxisome proliferator-activated receptor γ (PPARγ), controls blood sugar level by improving insulin sensitivity in the periphery and liver. It can be taken on an empty stomach or with a meal. VI. Insulin: Insulin is the most effective treatment for diabetes with the least adverse effects, and is beneficial for the prevention of comorbidities in diabetes. According to the type of insulin, such as the choice of genetic recombinant human insulin (Novolin R, Novolin 30R), to determine the time of meal, it needs to be injected subcutaneously 30 minutes before the meal, such as the choice of insulin analogues (Novolac, Novolac 30), it needs to be injected subcutaneously within 15 minutes before the meal. As the mechanism of action of each type of hypoglycemic drugs are different, so the time required for medication is not the same, if the time to take medication is not correct, it is difficult to play the role of lowering blood sugar. It can be seen that the usage of hypoglycemic drugs is very delicate, improper usage will get half the result with twice the effort. According to the mechanism of action of the drugs and the patient’s reaction to the drugs, reasonable adjustment of the time of taking the drugs can not only improve the efficacy, but also avoid toxic side effects and adverse reactions.