It is possible to have fever and sweating while sleeping during pneumonia treatment. Pneumonia is an inflammation of the terminal airways, alveoli, and interstitium of the lungs that can be caused by pathogenic microorganisms, physical and chemical factors, immune injury, allergies, and medications. Bacterial pneumonia is the most common type of pneumonia and one of the most common infectious diseases. Fever refers to the dysfunction of the body’s thermoregulatory center under the action of a pyrogen or various causes, and the body temperature rises beyond the normal range. Pneumonia has the potential to cause dysfunction of the body’s thermoregulatory center, causing fever, and sweating is one of the most important ways for the body to dissipate heat. Pneumonia patients in the treatment period when sleeping fever, sweating, may be the recurrence of the disease, in addition to the need to rule out the possibility of a combination of tuberculosis and other diseases. If the patient has fever and sweating while sleeping during treatment, it is recommended to inform the doctor of the situation and follow the doctor’s instructions, so as to avoid delaying the condition or causing adverse consequences by self-medication.