While the advent of in vitro fertilization (IVF) has helped many infertile couples, close to half of the current IVF births in the United States are from multiple pregnancies, which greatly increases the perinatal risk to both mother and newborn. In the past, IVF was evaluated on pregnancy success and infant live birth rates, but to reduce perinatal risks to mother and infant, producing a healthy infant is now the goal IVF pursues. Using data from 82,508 IVF cases nationwide after 2011, the CDC defined a good perinatal outcome as a full-term singleton delivery of a normal weight newborn and stratified the analysis according to prognosis (categorized as very good, slightly good, or average), maternal age, number of embryos implanted, and embryonic stage (3 days or 5 days). The results found that for patients with a very good prognosis (first IVF with additional frozen blastocysts), transfer of one 5-day or 3-day embryo resulted in a better perinatal outcome in the 35- and 35-37-year-old age groups; for patients with a slightly good prognosis (history of IVF, no history of delivery, no additional frozen blastocysts), transfer of two 3-day embryos resulted in a better perinatal outcome in the under-35-year-old age group; and for patients with an average prognosis of patients, under 35 years of age, transferring one 5-day-old blastocyst, or two 3-day-old blastocysts, and better perinatal outcomes with two 3-day-old embryos in the 35-37 and 38-40 years of age groups.