Diarrhea at the same time and accompanied by fever, generally first considered to be bacterial infectious diarrhea, viral infectious diarrhea or acute appendicitis, etc., should be promptly consulted to find out the cause of the disease. 1. Bacterial infectious diarrhea: generally caused by Escherichia coli, Salmonella spp. and other bacteria, the use of anti-inflammatory, antidiarrheal, antipyretic drugs for treatment, such as the use of penicillin amoxicillin and other penicillins, cephalosporins such as cephalosporins for anti-inflammatory treatment, oral montelukast for antidiarrheal treatment. At the same time, you can also use drugs such as safranin to achieve the purpose of sterilization, anti-inflammatory. 2. Viral diarrhea: generally caused by norovirus, coronavirus and so on. If viral infection is diagnosed, symptomatic treatment and supportive therapy are needed. 3. Acute appendicitis: Acute appendicitis is usually caused by obstruction of the appendix lumen and bacterial infection. Once appendicitis is diagnosed, appendectomy should be performed as soon as possible in the early stages. In addition, inflammatory bowel disease in the acute stage can also appear diarrhea and fever, if necessary, patients are recommended to improve the abdominal CT and colonoscopy to clarify the cause of the disease. Diarrhea patients should be more water, pay attention to rest, diet should be light and easy to digest food, avoid spicy, stimulating food, pay attention to personal hygiene, wash your hands before and after meals. Patients should follow the doctor’s instructions to actively cooperate with the doctor’s treatment, do not blindly use their own medicine, so as not to delay the condition or cause adverse reactions.