Low progesterone to eat progesterone and dydrogesterone are available, the difference in efficacy between the two is not significant, but the dydrogesterone adverse reactions less, so more recommended dydrogesterone. Progesterone and dydrogesterone both pharmacological mechanism although there are some differences, but can be used to supplement progesterone deficiency. Progesterone will inhibit the ovulation process to a certain extent, while dydrogesterone usually does not inhibit ovulation, so for women of childbearing age, the use of dydrogesterone may still be pregnant, so for premenstrual syndrome, secondary amenorrhea and other diseases, the use of dydrogesterone is recommended. In addition, dextroprogesterone has fewer adverse effects, making it more suitable for clinical development. However, dextroprogesterone is contraindicated in the presence of drug allergy, known or suspected progesterone-dependent tumors, unexplained vaginal bleeding, severe hepatic impairment, and hepatic tumors. All of the above drugs should be used under the supervision of clinicians.