Recurrent miscarriage is a common disease in the field of obstetrics and gynecology, with complex etiology and often ineffective traditional fertility preservation treatment, and has become an important cause of harm to women’s reproductive health. The causes of recurrent miscarriage are genetic, anatomical, endocrine, infection, immune and other factors. In addition to the above factors, there are still 40% to 80% of unknown causes, which cause great physical and psychological burdens to patients. Zhang Xiaoyan, Department of Obstetrics and Gynecology, First Affiliated Hospital of Zhengzhou University Diagnosis of recurrent miscarriage (habitual miscarriage) Recurrent miscarriage refers to miscarriage or embryonic arrest occurring 2 or more times in a row in a natural state (not caused by human purposes), and if it occurs 3 or more times, it is called habitual miscarriage. Couples with recurrent miscarriage (habitual miscarriage) need the following tests: chromosome analysis for both spouses; blood group test for both spouses; chromosome analysis for embryonic abortion products; semen test for the male partner; gynecological ultrasound for women; sex hormone six, glucose tolerance test and thyroid function test for women; infertility antibody screening and closed antibody test; TORCH test; hysteroscopy, etc. Comprehensive prevention and treatment of recurrent miscarriage (habitual miscarriage) 1. promptly go to the hospital for necessary examinations to exclude or clarify the cause; 2. for recurrent miscarriage (habitual miscarriage) with a clear cause, treat the cause and choose an appropriate pregnancy test under the guidance of the doctor; 3. for recurrent miscarriage with an unclear cause or negative closed antibody, immunotherapy can be chosen as a preventive method. Immunotherapy for recurrent miscarriage (habitual abortion) Some recurrent miscarriages of unknown cause occur as a result of immune rejection due to imbalance of immune status between mother and fetus. Active immunotherapy by individualized treatment, i.e., immunotherapy using special lymphocytes from spouses or unrelated healthy individuals, can suppress the cellular immune rejection between mother and fetus and reduce the rate of miscarriage. The results of clinical trials have shown that the success rate of pregnancy is significantly higher after active immunization, and the physiological indicators of the newborn are not different compared to the same indicators in normal newborns.