Gastric neuroendocrine tumor and gastric cancer are different in terms of etiology, pathology, clinical manifestation, auxiliary examination and treatment. 1. Etiology: gastric neuroendocrine tumor may be related to atrophic gastritis and gastrinoma. Gastric cancer is mostly related to Helicobacter pylori, dietary habits, chronic atrophic gastritis and heredity. 2. Pathology: gastric neuroendocrine tumors may have proliferation of G-cells, enterochromaffin-like cells, etc. Immunohistochemistry chromogranin A (CgA) and synaptophysin (Syn) are specific markers. Most gastric carcinomas are adenocarcinomas with abnormal proliferation of mucous gland cells. 3. Clinical manifestations: gastric neuroendocrine tumors may manifest as belching, heartburn, acid reflux, gastric pain, gastrointestinal bleeding and so on. Gastric cancer mainly manifests as epigastric discomfort or pain, emaciation and so on. 4. Auxiliary examination: gastric neuroendocrine tumor mainly has elevated gastrin, imaging examination finds mass, gastroscopic biopsy shows neuroendocrine tumor. Gastric cancer will have elevated CA199 level, and imaging examination will find mass; gastroscopic biopsy will show atypical hyperplasia of tumor cells. 5. Treatment: Gastric neuroendocrine tumors need to be selected according to the type, benignness and malignancy and malignancy degree, such as endoscopy, tumor resection, radical surgery, and so on, and those with high malignancy degree need to cooperate with chemotherapy and other treatment modes. Gastric cancer generally requires radical surgery, chemotherapy, immunotherapy and other comprehensive treatments. Neuroendocrine tumors and gastric cancer can be differentiated by clinical manifestations and various examinations, so it is recommended that patients should consult a doctor in time, follow the advice of specialists, clarify the causes of the disease, and standardize the diagnosis and treatment.