Higher total bilirubin and indirect bilirubin may indicate liver disease, hemolytic jaundice and so on. 1. Liver diseases: such as immune liver disease, chronic viral hepatitis, cirrhosis, drug-induced liver injury, cholestatic jaundice, etc., there will be damage to the liver cells, which will cause bilirubin metabolism abnormality, resulting in high total bilirubin and indirect bilirubin. 2. Hemolytic jaundice: In hemolytic jaundice, a large number of red blood cells are destroyed and a large amount of unconjugated bilirubin is formed, which weakens the metabolism of bilirubin by the liver cells, resulting in a slightly higher total bilirubin and indirect bilirubin. There are many causes of high total bilirubin and indirect bilirubin, so it is recommended that patients go to the gastroenterology department of the hospital for examination in a timely manner, so that the cause can be clarified under the guidance of the doctor and treatment can be carried out.