Liquid nitrogen cryotherapy is a common form of physical therapy in dermatology. This treatment mainly targets some skin lesions on the surface of the skin, and through the low temperature of liquid nitrogen, it induces necrosis on the skin lesions, and the necrotic tissues will gradually crust over and peel off, eventually causing the skin tissues in the area to regrow and repair again. Liquid nitrogen cryotherapy is generally widely used in clinical practice, usually in most cases for fibroids or HPV-infected warts, plantar warts, flat warts, etc., with obvious efficacy. For some sexually transmitted diseases, such as condyloma acuminatum can also be treated, but condyloma acuminatum needs to be treated with immunomodulators after the use of liquid nitrogen freezing. Liquid nitrogen freezing is not suitable for all skin lesions, and it is not effective for skin hyperplasia, such as lipomas or large tumors arising from other areas.