The cost of neonatal atrial septal defect surgery varies from one level of hospital to another, from one city level to another, and from one nature to another. The final cost of surgery for neonatal atrial septal defect is also different for different types of health insurance, and for different severity of the condition. In general, simple atrial septal defects that require only interventional surgery cost around $20,000, and if the infant’s general condition is poor and medications need to be given before or after surgery, an additional $5,000-$10,000 may be required. For infants with complications other than simple atrial septal defect, if open-heart surgery is performed, the cost of surgery is more expensive, around $60,000, plus the cost of preoperative and postoperative medications.