The basic causes of GERD include impaired anti-reflux structure and function; reduced esophageal clearance; and reduced esophageal mucosal resistance; of which treatments include medications such as mosapride, lifestyle modification, and surgical treatment. 1. Pharmacological treatment: the drugs used in the treatment of gastroesophageal reflux include acid-suppressing drugs and gastrointestinal stimulants, of which the commonly used acid-suppressing drugs include proton pump inhibitors and H2 receptor antagonists, and the commonly used gastrointestinal stimulants include domperidone, mosapride and itopride. 2. Lifestyle regulation: the patient’s body position has a certain effect on gastroesophageal reflux, the patient can raise the head of the bed to intervene in the reflux, and the patient should also pay attention to not eat before going to bed. 3. Surgery: The main purpose is to stop the reflux of gastric contents, and laparoscopic fundoplication can be used. The above mentioned medications should not be used by patients on their own.