The best and fastest way to get rid of yellow phlegm is, of course, to treat it with antibiotics. If the yellow sputum is caused by an upper respiratory tract infection, it can be treated with oral antibiotics. For upper respiratory tract infections, if there is no allergy to penicillin, you can use amoxicillin or amoxicillin clavulanate potassium, which is particularly effective for upper respiratory tract infections. If there is no allergy to cephalosporins, you can also use cefadroxil or cefaclor for treatment. In addition, if the lower respiratory tract infection caused by coughing up yellow sputum, more serious, the first need to intravenous drip antibiotics for treatment, preferred penicillin drugs, if penicillin has an allergic condition, you can use cephalosporin antibiotics, such as ceftriaxone, levofloxacin, the effect is better. In case of children, it is better to use cefoperazone, which is more effective. In addition, you need to combine the use of cough and phlegm drugs, is the best and fastest way to get rid of yellow phlegm, for example, you can use the lung force cough combination.