You can take metformin with risperidone, and there is no evidence-based evidence that the two would conflict. Risperidone is used for schizophrenia and bipolar disorder; metformin is used for type 2 diabetes mellitus not controlled by exercise and diet. It is possible to take metformin while taking risperidone, and there is no relevant evidence-based evidence that the two would conflict. Common adverse reactions to risperidone are dizziness, blurred vision, dyspepsia, nausea, vomiting, epigastric pain, diarrhea, dry mouth, fatigue, and rash. Contraindications are prohibited for those who are allergic to the product. Common adverse reactions to metformin are nausea, vomiting, abdominal pain, heartburn, and dizziness. Contraindications are hypersensitivity to it, heart failure, hepatic and renal insufficiency. Risperidone and Metformin should be used under the guidance of a physician and should not be taken on its own to avoid adverse consequences.