Drinking more water will not cause the antibody titer to become negative, there is no direct correlation between the two, the change of antibody titer is mainly affected by time and the immune status of the body. After vaccination or exposure to the corresponding pathogens, the body will produce antibodies against the corresponding pathogens, and there will be a certain amount of antibodies in the body, and the antibody titer can be measured through examination. After drinking water, the blood level in the body is basically stable as the body metabolizes it. Drinking large amounts of water will not produce significant changes, and therefore will not significantly affect the antibody titer. However, the antibody titer will gradually weaken over time. The antibody titer can be used to determine whether the body is infected with the relevant pathogens or to assess the resistance to the relevant pathogens. If some of the antibodies are found to be significantly weakened or negative, vaccination can be carried out under the guidance of the clinician to further enhance immunity.