Hepatitis B 1 and 4 positive indicates that the organism is infected with the hepatitis B virus, and the level of hepatitis B virus replication is generally low. Hepatitis B serologic markers are generally sequential, often referred to as the two halves, the first being hepatitis B surface antigen, the second being hepatitis B surface antibody, the third being hepatitis B e antigen, the fourth being hepatitis B e antibody, and the fifth being hepatitis B core antibody. 1 and 4 positive items are positive for surface antigen and positive for e antibody. If the surface antigen is positive, it means that the person is infected with hepatitis B virus, while the hepatitis B e antibody is positive, which indicates that the amount of virus replication is not large or is at a low level of replication. Generally, items 1 and 4 are rarely positive alone, but usually items 1, 4 and 5 are positive, i.e. small triplets. If the quantitative hepatitis B virus is also heavily replicated in small triplets, it indicates that there is a mutation of the hepatitis B virus.