Platelet count 466×10⁹/L is abnormal for thrombocytosis, which can be categorized into primary and secondary increase. 1. Primary increase: mostly seen in myeloproliferative diseases, such as primary thrombocythemia, chronic granulocytic leukemia, early myelofibrosis. For primary thrombocytosis, drugs such as hydroxyurea should be given to control the proliferation of bone marrow, and aspirin can also be used to prevent thrombosis. 2. Secondary increase: the degree of such thrombocytosis is mild, mostly seen in acute infections, some cancer patients and acute hemolytic disease. For example, patients with acute bacterial infection should be treated with levofloxacin and other anti-infective drugs. The normal value of platelet count is (100~300)×10⁹/L, and platelet count over 400×10⁹/L is thrombocytosis. If thrombocytosis occurs, it is recommended to seek medical attention as soon as possible to identify the cause and receive medication under the guidance of a physician.