Calcific defense refers to calcific uremic microarteriopathy, a cutaneous vascular disease that is potentially fatal and occurs in four locations, including the extremities, buttocks, breasts, and abdomen, and usually presents with symptoms such as thrombotic occlusion and tissue ischemic necrosis. It is usually caused by calcium deficiency and should be diagnosed early and treated promptly. Usually, we should pay attention to calcium supplementation, can take oral calcium or calcium tablets, eat more calcium-containing foods, more sunshine, so that the body synthesizes calcium elements, and strengthen physical exercise.